Clinical endocrinology (Oxford), 2002-07, Vol.57 (1), p.131-134
2002
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Details
- Autor(en) / Beteiligte
- Titel
- Ectopic growth hormone‐releasing hormone secretion by thymic carcinoid tumour
- Ist Teil von
- Clinical endocrinology (Oxford), 2002-07, Vol.57 (1), p.131-134
- Ort / Verlag
- Oxford, UK: Blackwell Science Ltd
- Erscheinungsjahr
- 2002
- Quelle
- Wiley Online Library - AutoHoldings Journals
- Beschreibungen/Notizen
- Summary The case of a 33‐year‐old‐woman with Multiple Endocrine Neoplasia Type 1 (MEN1) syndrome and acromegaly due to ectopic growth hormone‐releasing hormone (GHRH) secretion by a thymic carcinoid tumour is reported. Immunohistochemistry revealed positive immunoreactivity for GHRH, vasoactive intestinal polypeptide, somatostatin and alpha‐subunit in the tumour cells. A previously undescribed new germ line mutation of the MEN1 protein gene was revealed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0300-0664eISSN: 1365-2265DOI: 10.1046/j.1365-2265.2002.01535.xTitel-ID: cdi_proquest_miscellaneous_71889562
- Format
- –
- Schlagworte
- Acromegaly - drug therapy, Acromegaly - etiology, Adult, Antineoplastic Agents - therapeutic use, Biological and medical sciences, Carcinoid Tumor - chemistry, Carcinoid Tumor - drug therapy, Carcinoid Tumor - metabolism, Endocrinopathies, Fatal Outcome, Female, General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes, Germ-Line Mutation, Growth Hormone-Releasing Hormone - analogs & derivatives, Growth Hormone-Releasing Hormone - analysis, Growth Hormone-Releasing Hormone - metabolism, Humans, Immunohistochemistry, Medical sciences, Multiple Endocrine Neoplasia Type 1 - chemistry, Multiple Endocrine Neoplasia Type 1 - drug therapy, Multiple Endocrine Neoplasia Type 1 - genetics, Multiple Endocrine Neoplasia Type 1 - metabolism, Neoplasm Proteins - analysis, Neoplasm Proteins - metabolism, Peptides, Cyclic - therapeutic use, Pneumology, Somatostatin - analogs & derivatives, Somatostatin - analysis, Somatostatin - therapeutic use, Thymus Neoplasms - chemistry, Thymus Neoplasms - metabolism, Tumors of the respiratory system and mediastinum, Vasoactive Intestinal Peptide - analysis