Details

Autor(en) / Beteiligte

• Algün, E.
• Topal, C.
• Öztürk, M.
• Ramazan şekeroǦlu, M.
• Durmuş, A.

Titel

Urinary beta-2 microglobulin in renal dysfunction associated with hypothyroidism

Ist Teil von

• International journal of clinical practice (Esher), 2004-03, Vol.58 (3), p.240-243

Ort / Verlag

Oxford, UK, Malden , USA: Blackwell Science Ltd

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Hypothyroidism is associated with a number of functional renal disorders primarily affecting water and salt handling. In this study, we aim to investigate functional renal disorders in overt and subclinical hypothyroidism. We utilised urinary beta‐2 microglobulin (β2M) as a sensitive marker of tubular dysfunction. Urinary β2M excretion and tests for renal functions were repeated before and after T4 replacement therapy. Forty‐four patients (28 with overt disease, 16 with subclinical disease) and 31 healthy control subjects were involved in the study. There was a significant increase in urinary β2M in both overt and subclinical hypothyroidism (p < 0.05 in both). TSH levels were correlated with β2M excretion. Effects of hypothyroidism on renal functions were readily reversible by 3 weeks of thyroid hormone replacement therapy. Urinary β2M was a sensitive marker of renal tubular dysfunction associated with overt and subclinical hypothyroidism.