Details

Autor(en) / Beteiligte

• OTTAIANO, Alessandro
• DE CHIARA, Anna
• PISANO, Carmela
• NAPOLITANO, Maria
• ASCIERTO, Paolo Antonio
• IAFFAIOLI, Rosario Vincenzo
• APICE, Gaetano
• PERRONE, Francesco
• BOTTI, Gerardo
• FAZIOLI, Flavio
• DE ROSA, Vincenzo
• MOZZILLO, Nicola
• RAVO, Vincenzo
• MORRICA, Brunello
• GALLO, Ciro

Titel

Prognostic Value of CD40 in Adult Soft Tissue Sarcomas

Ist Teil von

• Clinical cancer research, 2004-04, Vol.10 (8), p.2824-2831

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose: The purpose is to evaluate the expression of CD40, a membrane protein predominantly expressed on B cells, dendritic cells, and macrophages, in a series of adult soft tissue sarcomas and to test its possible prognostic value. Experimental Design: CD40 expression was studied by immunohistochemistry. Correlations with other baseline characteristics of patients and tumors were analyzed with χ 2 test. The prognostic value was studied with univariable and multivariable analysis adjusted by age, sex, tumor size, grade, location, and distant metastases. Results: Eighty-two patients, between January 1994 and May 2001, were analyzed. Membrane or cytoplasmic staining for CD40 protein was absent in 30% of the tumors but present in <10% of cells in 22 (27%), in 10% to 50% in 23 (28%), and in >50% of cells in 12 (15%) tumors. There was no correlation between CD40 expression and age, sex, size, grade, and location of the primary tumor and distant metastases. With 61 patients (74.4%) progressed and 31 (37.8%) dead, CD40 expression was a significant prognostic factor for disease-free and overall survival at univariable and multivariable analysis. Patients with tumors expressing CD40 in >50% of cells had a dramatically unfavorable prognosis with median disease-free and overall survival of 7 and 17 months, respectively, and hazard ratios of relapse and death as compared with patients with CD40-negative tumors of 2.89 (95% confidence interval: 1.26–6.60) and 6.92 (95% confidence interval: 2.18–22.0), respectively. Conclusions: These data suggest that expression of CD40 protein in >50% of cells might indicate an unfavorable prognosis in adult soft tissue sarcomas.