Cancer research (Chicago, Ill.), 2002-06, Vol.62 (12), p.3347-3350
2002
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Details
- Autor(en) / Beteiligte
- Titel
- Human cytomegalovirus infection and expression in human malignant glioma
- Ist Teil von
- Cancer research (Chicago, Ill.), 2002-06, Vol.62 (12), p.3347-3350
- Ort / Verlag
- Philadelphia, PA: American Association for Cancer Research
- Erscheinungsjahr
- 2002
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Malignant gliomas are the most common primary brain tumors in adults, have no known etiology, and are generally rapidly fatal despite current therapies. Human cytomegalovirus (HCMV) is beta-herpesvirus trophic for glial cells that persistently infects 50-90% of the adult human population. HCMV can be reactivated under conditions of inflammation and immunosuppression, and HCMV gene products can dysregulate multiple cellular pathways involved in oncogenesis. Here we show that a high percentage of malignant gliomas are infected by HCMV and multiple HCMV gene products are expressed in these tumors. These data are the first to show an association between HCMV and malignant gliomas and suggest that HCMV may play an active role in glioma pathogenesis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0008-5472eISSN: 1538-7445Titel-ID: cdi_proquest_miscellaneous_71833291
- Format
- –
- Schlagworte
- Astrocytoma - metabolism, Astrocytoma - pathology, Astrocytoma - virology, Biological and medical sciences, Brain Neoplasms - metabolism, Brain Neoplasms - pathology, Brain Neoplasms - virology, Cell physiology, Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes, Cytomegalovirus - genetics, Cytomegalovirus - metabolism, Cytomegalovirus Infections - complications, Cytomegalovirus Infections - metabolism, DNA, Viral - genetics, DNA, Viral - metabolism, Fundamental and applied biological sciences. Psychology, Gene Expression, Genes, Viral, Glioma - metabolism, Glioma - pathology, Glioma - virology, Humans, Immediate-Early Proteins - biosynthesis, Immediate-Early Proteins - genetics, Immunohistochemistry, In Situ Hybridization, Medical sciences, Meningioma - metabolism, Meningioma - pathology, Meningioma - virology, Molecular and cellular biology, Neurology, Tumors of the nervous system. Phacomatoses, Viral Proteins