Details

Autor(en) / Beteiligte

• de Haij, Simone
• Daha, Mohamed R.
• Kooten, Cees van

Titel

Mechanism of steroid action in renal epithelial cells

Ist Teil von

• Kidney international, 2004-05, Vol.65 (5), p.1577-1588

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• Mechanism of steroid action in renal epithelial cells. Renal tubular epithelial cells (TEC) are thought to play an active role in tubulointerstitial inflammation. Various immune and non-immune factors activate TEC to produce a variety of cytokines and chemokines, contributing to attraction of inflammatory cells to the kidney. The proinflammatory transcription factor nuclear factor-κB (NF-κB) appears to be a key player in these responses and tubular expression of NF-κB has been demonstrated in vitro and in vivo. Although glucocorticoids are known to inhibit NF-κB activation at different levels, the proinflammatory capacity of TEC was not inhibited. In contrast, glucocorticoids seemed to enhance the profibrotic response of TEC, emphasizing the cell-type specific characteristics of glucocorticoid action. We propose that specific inhibition of NF-κB activation in TEC might be an attractive strategy for therapeutic intervention in renal inflammation.