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Placental massive perivillous fibrin deposition associated with antiphospholipid antibody syndrome
Ist Teil von
BJOG : an international journal of obstetrics and gynaecology, 2002-05, Vol.109 (5), p.570-573
Ort / Verlag
Oxford, UK: Blackwell Science Ltd
Erscheinungsjahr
2002
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
We present three pregnancies in which massive perivillous fibrous deposition (MPVFD) and maternal floor infarction (MFI) occurred in patients with primary antiphospholipid antibody syndrome (PAPS) attending a recurrent miscarriage clinic, and who were treated with low dose aspirin and heparin. We hypothesise that PAPS may be a predisposing factor to the development of this condition. The increased prevalence of late pregnancy complications in PAPS patients with a history of early miscarriage suggests that aspirin and heparin therapy does not eradicate the underlying pathological process but merely reduces the severity. Therefore, untreated early pregnancy losses may be converted into treated pregnancies with late antenatal complications. Some patients with PAPS may therefore be prone to suffer either the previously reported complications of the uteroplacental vasculature, such as pre‐eclampsia, and/or specific complications related to the environment of the intervillus space, such as MPVFD/MFI.