Details

Autor(en) / Beteiligte

• Meineche‐Schmidt, V.
• Hauschildt Juhl, H.
• Østergaard, J. E.
• Luckow, A.
• Hvenegaard, A.

Titel

Costs and efficacy of three different esomeprazole treatment strategies for long‐term management of gastro‐oesophageal reflux symptoms in primary care

Ist Teil von

• Alimentary pharmacology & therapeutics, 2004-04, Vol.19 (8), p.907-915

Ort / Verlag

Oxford, UK: Blackwell Science Ltd

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Background : A prospective, open, randomized multi‐centre study with parallel group design was conducted in 155 general practice clinics, and included 1357 endoscopically uninvestigated patients with symptoms suggestive of gastro‐oesophageal reflux disease. Aim : To assess the differences in direct medical costs between a patient‐controlled on‐demand treatment strategy with esomeprazole, 20 mg daily, and general practitioner‐controlled intermittent treatment strategies with esomeprazole, 40 mg daily, for either 2 or 4 weeks. Secondary objectives were to measure other costs, total costs, patient satisfaction and time to first relapse. Methods : The primary cost analysis was carried out as a cost minimization analysis, comparing the direct medical costs in patients allocated to on‐demand treatment vs. those in patients allocated to either of the intermittent treatment strategies. Results : The mean direct medical costs were 182, 221 and 195 euros for patient‐controlled on‐demand treatment and 2 weeks and 4 weeks of general practitioner‐controlled intermittent treatment, respectively, showing no statistically significant difference. The comparable mean total costs were 211, 344 and 300 euros, i.e. significantly lower for patients treated on‐demand compared with either of the general practitioner‐controlled intermittent treatment strategies. Conclusions : The mean total costs, but not the mean direct medical costs, were higher in general practitioner‐controlled intermittent treatment strategies with esomeprazole compared with a patient‐controlled on‐demand treatment strategy.