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Helicobacter pylori in North and South America before Columbus
Ist Teil von
FEBS letters, 2002-04, Vol.517 (1), p.180-184
Ort / Verlag
England: Elsevier B.V
Erscheinungsjahr
2002
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
We present a molecular epidemiologic study, based on an analysis of
vacA,
cagA and
cag right end junction genotypes from 1042
Helicobacter pylori isolates, suggesting that
H. pylori was present in the New World before Columbus. Eight Native Colombian and Alaskan strains possessed novel
vacA and/or
cagA gene structures and were more closely related to East Asian than to non-Asian
H. pylori. Some Native Alaskan strains appear to have originated in Central Asia and to have arrived after strains found in South America suggesting that
H. pylori crossed the Bering Strait from Asia to the New World at different times.