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Activated Mitogen-activated Protein Kinase Expression during Human Breast Tumorigenesis and Breast Cancer Progression
Ist Teil von
Clinical cancer research, 2002-06, Vol.8 (6), p.1747-1753
Ort / Verlag
Philadelphia, PA: American Association for Cancer Research
Erscheinungsjahr
2002
Quelle
MEDLINE
Beschreibungen/Notizen
Purpose: The purpose of this study is to address the hypothesis that activatedmitogen-activated protein kinase (MAPK; extracellular
signal-regulated kinases 1 and 2) has a role in breast tumorigenesis, breast cancer progression, and the development of tamoxifen
resistance.
Experimental Design: H-score analysis and a specific antibody for the immunohistochemical detection of activated MAPK in formalin-fixed, paraffin-embedded
tissue sections were used to compare expression in: ( a ) human breast tumors and their matched adjacent normal breast tissue; ( b ) primary human breast tumors and their matched lymph node metastases; and ( c ) primary breast tumors from patients who later proved to be sensitive or resistant to tamoxifen treatment.
Results: Active MAPK expression was detected in 48% of primary human breast tumors and was significantly increased in tumors compared
with adjacent normal breast (Wilcoxon test, P = 0.027). A significant positive association (χ 2 , P = 0.02; n = 55) was obtained between active MAPK and the presence of lymph node metastases. Moreover, increased active MAPK (Wilcoxon
test, P = 0.0098) was found in concurrent lymph node metastases compared with primary breast tumors. No significant difference in
active MAPK was found in primary tumors of patients who later responded to tamoxifen or did not respond to tamoxifen.
Conclusions: These data suggest that active MAPK is a marker of breast cancer metastasis and has a role in the metastatic process. However,
active MAPK is unlikely to be a marker of endocrine sensitivity or involved in de novo tamoxifen resistance.