Details

Autor(en) / Beteiligte

• Gwehenberger, Birgit
• Rist, Lukas
• Huch, Renate
• von Mandach, Ursula

Titel

Effect of Bryophyllum pinnatum versus fenoterol on uterine contractility

Ist Teil von

• European journal of obstetrics & gynecology and reproductive biology, 2004-04, Vol.113 (2), p.164-171

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

2004

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective: To characterise the phytotherapeutic tocolytic Bryophyllum pinnatum in vitro versus the conventional betamimetic, fenoterol, in human myometrium. Study design: Contractility (endpoints: area under the curve (AUC), amplitude and frequency of isometric force development) was measured in strips of term myometrium biopsied at caesarean section in 14 women and exposed to increasing concentrations of B. pinnatum versus fenoterol±oxytocin 1 U/l. Results: Inhibition of spontaneous contraction by B. pinnatum was concentration-dependent: 16% at maximum concentration (10 4 mg/l), or 53% that with fenoterol 5×10 −8 mol/l. B. pinnatum increased contraction frequency by 91% at constant amplitude and inhibited oxytocin-stimulated contractions by 20% (AUC) at constant amplitude with slightly decreased frequency. Fenoterol decreased contraction AUC by 50% with a significant decrease in frequency. Conclusion: Our in vitro data confirm the tocolytic activity of B. pinnatum observed in alternative medicine centres and may justify further clinical studies.