Immunity (Cambridge, Mass.), 2002-05, Vol.16 (5), p.697-706
2002
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Failure of Trafficking and Antigen Presentation by CD1 in AP-3-Deficient Cells
- Ist Teil von
- Immunity (Cambridge, Mass.), 2002-05, Vol.16 (5), p.697-706
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2002
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Endocytosed microbial antigens are primarily delivered to lysosomal compartments where antigen binding to MHC and CD1 molecules occurs in an acidic and proteolytically active environment. Signal-dependent delivery to lysosomes has been suggested for these antigen-presenting molecules, but molecular interactions with vesicular coat proteins and adaptors that direct their lysosomal sorting are poorly understood. Here CD1b but not other CD1 isoforms bound the AP-3 adaptor protein complex. In AP-3-deficient cells derived from patients with Hermansky-Pudlak syndrome type 2 (HPS-2), CD1b failed to efficiently gain access to lysosomes, resulting in a profound defect in antigen presentation. Since MHC class II traffics normally in AP-3-deficient cells, defects in CD1b antigen presentation may account for recurrent bacterial infections in HPS-2 patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1074-7613eISSN: 1097-4180DOI: 10.1016/S1074-7613(02)00311-4Titel-ID: cdi_proquest_miscellaneous_71796119
- Format
- –
- Schlagworte
- Adaptor Proteins, Vesicular Transport, Amino Acid Motifs, Antigen Presentation, Antigens, Bacterial - immunology, Antigens, CD - chemistry, Antigens, CD - metabolism, Antigens, CD1 - chemistry, Antigens, CD1 - metabolism, Antigens, CD1 - physiology, Bacterial Infections - immunology, Carrier Proteins - genetics, Carrier Proteins - metabolism, Cell Line, Charitable foundations, Gene Deletion, Glycoproteins - chemistry, Glycoproteins - metabolism, HeLa Cells, Humans, Immune system, Lipids - immunology, Lysosomes - metabolism, Lysosomes - ultrastructure, Macromolecular Substances, Membrane Proteins - genetics, Membrane Proteins - metabolism, Microscopy, Monomeric Clathrin Assembly Proteins, Peptides, Platelet Membrane Glycoproteins - chemistry, Platelet Membrane Glycoproteins - metabolism, Protein Isoforms - metabolism, Protein Transport, Proteins, Syndrome, Tetraspanin 30