Details

Autor(en) / Beteiligte

• Martin-Villalba, Ana
• Demjen, Deana
• Klussmann, Stefan
• Kleber, Susanne
• Zuliani, Cecilia
• Stieltjes, Bram
• Metzger, Corinna
• Hirt, Ulrich A
• Walczak, Henning
• Falk, Werner
• Essig, Marco
• Edler, Lutz
• Krammer, Peter H

Titel

Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury

Ist Teil von

• Nature medicine, 2004-04, Vol.10 (4), p.389-395

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2004

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The clinical outcome of spinal cord injury (SCI) depends in part on the extent of secondary damage, to which apoptosis contributes. The CD95 and tumor necrosis factor (TNF) ligand/receptor systems play an essential role in various apoptotic mechanisms. To determine the involvement of these ligands in SCI-induced damage, we neutralized the activity of CD95 ligand (CD95L) and/or TNF in spinal cord-injured mice. Therapeutic neutralization of CD95L, but not of TNF, significantly decreased apoptotic cell death after SCI. Mice treated with CD95L-specific antibodies were capable of initiating active hind-limb movements several weeks after injury. The improvement in locomotor performance was mirrored by an increase in regenerating fibers and upregulation of growth-associated protein-43 (GAP-43). Thus, neutralization of CD95L promoted axonal regeneration and functional improvement in injured adult animals. This therapeutic strategy may constitute a potent future treatment for human spinal injury.