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A nitrous oxide and oxygen mixture has been used for decades as an analgesic in midwifery, dental surgery, or traumatology with immediate pain relief lasting for up to 15 minutes following inhalation. A pilot study with nitrous oxide for breakthrough pain unresponsive to rescue opioids was performed in 10 cancer patients. Results suggest that the efficacy of nitrous oxide in cancer pain is still unproven. (Quotes from original text)