Details

Autor(en) / Beteiligte

• Hooper, W.Craig
• Lally, Cathy
• Austin, Harland
• Renshaw, Mary
• Dilley, Anne
• Wenger, Nanette Kass
• Phillips, Donald J
• Whitsett, Carolyn
• Rawlins, Peggy
• Evatt, Bruce L

Titel

The Role of the t-PA I/D and PAI-1 4G/5G Polymorphisms in African-American Adults With a Diagnosis of Myocardial Infarction or Venous Thromboembolism

Ist Teil von

• Thrombosis research, 2000-08, Vol.99 (3), p.223-230

Ort / Verlag

New York, NY: Elsevier Ltd

Erscheinungsjahr

2000

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• To determine whether or not the PAI-1 4G/5G and t-PA I/D polymorphisms in African-Americans were linked to cardiovascular disease, the association of these polymorphisms to disease expression was analyzed in a recently completed case-control study of myocardial infarction or venous thromboembolism among African-Americans. All African-Americans patients with a history of venous thromboembolism attending an anticoagulant clinic, and patients with a history of a MI attending a cardiology clinic at a large local urban public hospital were eligible for inclusion as cases in the study. In this study it was observed that there was a statistically significant association between the D allele of the t-PA I/D polymorphism and venous thromboembolism and a nonsignificant association between the D allele and myocardial infarction among African-Americans. t-PA antigen levels were statistically significantly higher among both myocardial infarction and venous thromboembolism cases compared with control subjects. The genotypes were unrelated to t-PA plasma levels. There was no association between either myocardial infarction or venous thromboembolism and the 4G/5G PAI-1 genotype. It was also found that genotype frequencies for both PAI-1 4G/5G and t-PA I/D polymorphisms in African-American adults were different from those reported for both U.S. Causcians and Europeans.