Details

Autor(en) / Beteiligte

• Jorajuria, S
• Clayette, P
• Dereuddre-Bosquet, N
• Larghero, J
• Thiebot, H
• Neildez, O
• Vaslin, B
• Le Grand, R
• Dormont, D

Titel

Evaluation of the effect of early and massive tritherapy on the expression of cellular factors potentially implicated in antiretroviral therapy resistance

Ist Teil von

• Pathologie biologie (Paris), 2000-06, Vol.48 (5), p.490-494

Ort / Verlag

France

Erscheinungsjahr

2000

Quelle

MEDLINE

Beschreibungen/Notizen

• Treatment of the human immunodeficiency virus (HIV) is restricted by therapeutic escape. The biological mechanisms of this chemoresistance rely notably on the modulation of cell kinase and P-glycoprotein (P-gp) expression. In this study, we investigated, in cynomolgus macaques, the roles of SHIV89.6P infection and of HAART in the mRNA expression of these cell factors. SHIV infection, or associated pathophysiological disorders, increase both thymidine kinase and thymidylate kinase mRNA expression and decrease those of P-gp. On the other hand, the expression of other cell kinases is not modulated. In parallel, HAART accentuates the decrease of P-gp expression and attenuates the increase of kinase expression. On the whole, such metabolic disorders, evidenced herein an animal model of HIV infection, could be involved in HIV-infected patients.