Details

Autor(en) / Beteiligte

• Gautschi, Jeffrey T
• Amagata, Taro
• Amagata, Akiko
• Valeriote, Frederick A
• Mooberry, Susan L
• Crews, Phillip

Titel

Expanding the Strategies in Natural Product Studies of Marine-Derived Fungi:  A Chemical Investigation of Penicillium Obtained from Deep Water Sediment

Ist Teil von

• Journal of natural products (Washington, D.C.), 2004-03, Vol.67 (3), p.362-367

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• Three previously unknown pentaketides, (+)-formylanserinone B (3), (−)-epoxyserinone A (4), and (+)-epoxyserinone B (5), along with two known fungal pigments, anserinones A (1) and B (2), were isolated and identified from a deep water (−4380 ft), marine-derived saltwater fungal culture. Two other minor constituents, hydroxymethylanserinone B (6) and deoxyanserinone B (7), were also isolated, but not completely purified. The structures of 3−7, each expanding the dense functionalization of the anserinones, were determined by dereplication and spectroscopic analysis. Bioactivity was explored in two separate cell-based assays. Leukemia selectivity was greatest with 2 and 3, while 1−3 exhibited modest activity against the MDA-MB-435 cell line.