Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
BACKGROUND: It has been previously reported that the number of circulating immature cells (CIC) in peripheral blood (PB) estimates the number of CD34+ cells collected in G‐CSF plus chemotherapy‐induced PBPC mobilization. The correlation of CIC counts in PB with CD34+ cell yield and its usefulness was evaluated in G‐CSF‐induced PBPC mobilization for healthy donors.
STUDY DESIGN AND METHODS: CIC counts in PB and CD34+ cell counts in the apheresis product from 122 collections were assessed, and the relationship between these two variables was evaluated with the Pearson rank correlation analysis, the chi‐squared test, and the U‐test.
RESULTS: CIC counts were correlated weakly with the number of CD34+ cells per L of blood processed in the apheresis product (Pearson rank correlation analysis; r = 0.357, p < 0.0001). When a level of 1.7 × 109 CICs per L was selected as a cutoff value, the sensitivity and specificity for collecting more than 20 × 106 CD34+ cells per L of blood processed were 63.6 and 77.5 percent, respectively.
CONCLUSION: The present study suggests that the number of CICs in PB may estimate the number of CD34+ cells collected. The data indicate that CIC counts above 1.7 × 109 per L can be used as a good predictor for PBPC collections containing more than 20 × 106 CD34+ cells per L of blood processed in a single apheresis procedure.