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Vegetables, Fruits, Legumes and Prostate Cancer: A Multiethnic Case-Control Study
Ist Teil von
Cancer epidemiology, biomarkers & prevention, 2000-08, Vol.9 (8), p.795-804
Ort / Verlag
Philadelphia, PA: American Association for Cancer Research
Erscheinungsjahr
2000
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
The evidence for a protective effect of vegetables, fruits, and legumes
against prostate cancer is weak and inconsistent. We examined the
relationship of these food groups and their constituent foods to
prostate cancer risk in a multicenter case-control study of
African-American, white, Japanese, and Chinese men. Cases
( n = 1619) with histologically confirmed prostate
cancer were identified through the population-based tumor registries of
Hawaii, San Francisco, and Los Angeles in the United States and British
Columbia and Ontario in Canada. Controls ( n = 1618)
were frequency-matched to cases on ethnicity, age, and region of
residence of the case, in a ratio of approximately 1:1. Dietary and
other information was collected by in-person home interview; a blood
sample was obtained from control subjects for prostate-specific antigen
determination. Odds ratios (OR) were estimated using logistic
regression, adjusting for age, geographic location, education,
calories, and when indicated, ethnicity. Intake of legumes (whether
total legumes, soyfoods specifically, or other legumes) was inversely
related to prostate cancer (OR for highest relative to lowest quintile
for total legumes = 0.62; P for trend =
0.0002); results were similar when restricted to prostate-specific
antigen-normal controls or to advanced cases. Intakes of yellow-orange
and cruciferous vegetables were also inversely related to prostate
cancer, especially for advanced cases, among whom the highest quintile
OR for yellow-orange vegetables = 0.67 ( P for
trend = 0.01) and the highest quintile OR for cruciferous
vegetables = 0.61 ( P for trend = 0.006).
Intake of tomatoes and of fruits was not related to risk. Findings were
generally consistent across ethnic groups. These results suggest that
legumes (not limited to soy products) and certain categories of
vegetables may protect against prostate cancer.