Cancer letters, 2004-03, Vol.205 (2), p.215-226
2004
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Details
- Autor(en) / Beteiligte
- Titel
- Expression and functional characterization of the system l amino acid transporter in KB human oral epidermoid carcinoma cells
- Ist Teil von
- Cancer letters, 2004-03, Vol.205 (2), p.215-226
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We have examined the expression and function of system l amino acid transporter in KB human oral epidermoid carcinoma cells. The KB cells express l-type amino acid transporter 1 (LAT1) in plasma membrane, but not l-type amino acid transporter 2 (LAT2). The [ 14C] l-leucine uptake by KB cells is inhibited by system l selective inhibitor BCH. The majority of [ 14C] l-leucine uptake is, therefore, mediated by LAT1. These results suggest that the transport of neutral amino acids including several essential amino acids into the KB cells mediated by LAT1 and the specific inhibition of LAT1 in oral cancer cells will be a new rationale for anti-cancer therapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2003.10.009Titel-ID: cdi_proquest_miscellaneous_71758584
- Format
- –
- Schlagworte
- Amino Acid Transport System y, Amino acids, Amino Acids, Cyclic - pharmacology, Anti-cancer therapy, Cell culture, Cell growth, Essential amino acids, Fusion Regulatory Protein 1, Light Chains - analysis, Humans, Immunohistochemistry, KB Cells - chemistry, KB human oral epidermoid carcinoma cells, l-Type amino acid transporter, Large Neutral Amino Acid-Transporter 1 - analysis, Large Neutral Amino Acid-Transporter 1 - physiology, Leucine - metabolism, Medical research, Oral cancer, Polyclonal antibodies, Proteins, Studies