Details

Autor(en) / Beteiligte

• Letson, G.William
• Shapiro, Craig N
• Kuehn, Deborah
• Gardea, Charlotte
• Welty, Thomas K
• Krause, David S
• Lambert, Stephen B
• Margolis, Harold S

Titel

Effect of maternal antibody on immunogenicity of hepatitis A vaccine in infants

Ist Teil von

• The Journal of pediatrics, 2004-03, Vol.144 (3), p.327-332

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

2004

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• To determine the effect of maternal antibody on hepatitis A vaccine immunogenicity in infants. Infants of mothers negative for antibody to hepatitis A virus (anti-HAV; group 1) were administered hepatitis A vaccine at 2, 4, and 6 months of age, and infants of anti-HAV–positive mothers were randomized to receive either hepatitis A vaccine (group 2) or hepatitis B vaccine (group 3) on the same schedule. Group 3 infants subsequently received hepatitis A vaccine at 8 and 10 months of age. At 15 months of age, 100% of infants in group 1, 93% in group 2, and 92% in group 3 had protective levels of antibody. However, there were significant differences in the geometric mean concentration (GMC) of anti-HAV between groups. Group 1 GMC was 231 mIU/mL, compared with 85 mIU/mL for group 2 and 84 mIU/mL for group 3 ( P<.001, group 1 vs group 3). Passively acquired maternal anti-HAV resulted in a significantly lower final antibody response when infants were administered hepatitis A vaccine at 2, 4, and 6 months of age or at 8 and 10 months of age.