Details

Autor(en) / Beteiligte

• Hien, Tran Tinh
• Liem, Nguyen Thanh
• Dung, Nguyen Thi
• San, Le Hoang
• San, Luong Thi
• Mai, Pham Phuong
• Mai, Le Thi Quynh
• Chau, Nguyen van Vinh
• Suu, Pham Thi
• Dong, Vo Cong
• Thi, Ngo Thi
• Khoa, Dao Bach
• Phat, Le Phuc
• Truong, Nguyen Thanh
• Long, Hoang Thuy
• Tung, Cao Viet
• Giang, Le Truong
• Tho, Nguyen Dac
• Nga, Le Hong
• Tien, Nguyen Thi Kim
• Tuan, Le Van
• Dolecek, Christiane
• Thanh, Tran Tan
• de Jong, Menno
• Schultsz, Constance
• Cheng, Peter
• Lim, Wilina
• Horby, Peter
• Farrar, Jeremy

Titel

Avian Influenza A (H5N1) in 10 Patients in Vietnam

Ist Teil von

• The New England journal of medicine, 2004-03, Vol.350 (12), p.1179-1188

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• This report describes the clinical details of 10 patients who were shown to have been infected with an H5N1 influenzavirus, which normally does not affect humans. The patients had direct contact with fowl a median of three days before they presented with fever, respiratory symptoms, and an acute influenza syndrome, characterized by lymphopenia and marked pulmonary infiltrates on chest radiography. Eight of the patients died, even though none had preexisting medical conditions. This report describes the clinical details of 10 patients who were shown to have been infected with an H5N1 influenzavirus. Eight of the patients died. Influenza A virus infects a variety of animals, including humans and birds. 1 Although the natural reservoir for all known subtypes of influenza A (hemagglutinins H1 through H15 and neuraminidases N1 through N9) is wild waterfowl, only three subtypes are currently circulating among humans (H1N1, H1N2, and H3N2). However, during the past few years, several subtypes of avian influenza A have been shown to cross the species barrier and infect humans. During an outbreak of a highly pathogenic influenza A (H5N1) virus among poultry in Hong Kong in 1997, 6 of 18 people with confirmed infection died. 2 After this outbreak, prevention . . .