UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 10 von 16
Datensatz exportieren als...
BibTeX
Role of amylin in insulin secretion and action in humans: antagonist studies across the spectrum of insulin sensitivity
Diabetes/metabolism research and reviews, 2002-03, Vol.18 (2), p.118-126
Mather, Kieren J.
Paradisi, Giancarlo
Leaming, Rosalind
Hook, Ginger
Steinberg, Helmut O.
Fineberg, Naomi
Hanley, Rochelle
Baron, Alain D.
2002
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Mather, Kieren J.
Paradisi, Giancarlo
Leaming, Rosalind
Hook, Ginger
Steinberg, Helmut O.
Fineberg, Naomi
Hanley, Rochelle
Baron, Alain D.
Titel
Role of amylin in insulin secretion and action in humans: antagonist studies across the spectrum of insulin sensitivity
Ist Teil von
Diabetes/metabolism research and reviews, 2002-03, Vol.18 (2), p.118-126
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2002
Quelle
Wiley-Blackwell Full Collection
Beschreibungen/Notizen
Background Amylin is a peptide co‐secreted with insulin by pancreatic β‐cells. A role for amylin in the pathogenesis of type 2 diabetes mellitus (DM2) has been suggested by in vitro and in vivo studies indicating an effect of amylin to cause insulin resistance and/or inhibit insulin secretion. Methods We have determined the effect of endogenous amylin on insulin secretion and insulin action in humans by performing 4‐h hyperglycemic clamps during infusion of placebo or a specific amylin receptor antagonist (ARA) in paired, double‐blinded, crossover studies. We studied nine healthy lean, ten healthy obese (BMI>27) and ten obesity‐matched DM2 subjects. Results Infusion of ARA alone had no effect on basal insulin, glucose or glucose turnover in any group. Under combined hyperglycemia and ARA infusion, lean subjects displayed a 32% augmentation in insulin levels [AUC 33 565±3556 (placebo) to 44 562±1379 (ARA) pmol/l/min, p<0.01]. The concomitant increase in glucose disposal rate (GDR) was proportionate, indicating no change in insulin sensitivity (ISI 27.7±2.7 vs 27.3±2.1, p=NS). In obese subjects, basal insulin and the rise in insulin during the clamp were greater (AUC I 44% increase from 82 054±15 407 to 117 922±27 085, p<0.01), and also accompanied by a proportionate rise in GDR reflecting an unchanged insulin sensitivity (ISI 12.1±2.9 vs 10.8±3.0, p=NS). In lean and obese subjects, the C‐peptide response to hyperglycemia was also augmented by ARA (p=0.007). No effect of ARA on insulin secretion or action was observed in diabetic subjects. Conclusions The present data are consistent with an effect of endogenous amylin on the β‐cell to modulate and/or restrain insulin secretion, and indicate that endogenous amylin does not affect insulin action. These observations provide the first human evidence that amylin plays a role in the modulation of insulin secretion. Copyright © 2002 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 1520-7552
eISSN: 1520-7560
DOI: 10.1002/dmrr.263
Titel-ID: cdi_proquest_miscellaneous_71716958
Format
–
Schlagworte
Adult
,
amylin
,
Amyloid - blood
,
Amyloid - physiology
,
Area Under Curve
,
Biological and medical sciences
,
Blood Glucose - metabolism
,
Body Mass Index
,
C-Peptide - blood
,
Diabetes Mellitus - blood
,
Diabetes Mellitus - physiopathology
,
Diabetes Mellitus, Type 2 - blood
,
Diabetes Mellitus, Type 2 - physiopathology
,
Diabetes. Impaired glucose tolerance
,
Endocrine pancreas. Apud cells (diseases)
,
Endocrinopathies
,
Etiopathogenesis. Screening. Investigations. Target tissue resistance
,
Female
,
Glucagon - blood
,
Glucose Clamp Technique
,
glucose disposal rate
,
Humans
,
hyperglycemic clamp
,
Insulin - metabolism
,
Insulin - physiology
,
insulin resistance
,
Insulin Secretion
,
insulin sensitivity
,
Islet Amyloid Polypeptide
,
Male
,
Medical sciences
,
Metabolic diseases
,
Obesity
,
Obesity - blood
,
Obesity - physiopathology
,
Receptors, Islet Amyloid Polypeptide
,
Receptors, Peptide - antagonists & inhibitors
,
Receptors, Peptide - blood
,
Reference Values
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX