Details

Autor(en) / Beteiligte

• Tripp, Ralph A.
• Moore, Deborah
• Barskey, Albert
• Jones, Les
• Moscatiello, Caminade
• Keyserling, Harry
• Anderson, Larry J.

Titel

Peripheral Blood Mononuclear Cells from Infants Hospitalized Because of Respiratory Syncytial Virus Infection Express T Helper-1 and T Helper-2 Cytokines and CC Chemokine Messenger RNA

Ist Teil von

• The Journal of infectious diseases, 2002-05, Vol.185 (10), p.1388-1394

Ort / Verlag

Chicago, IL: University of Chicago Press

Erscheinungsjahr

2002

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The cellular immune response to respiratory syncytial virus (RSV) infection was examined in infants aged 1-21 months who were hospitalized because of RSV infection or non-RSV-related illness. RSV- or control-stimulated peripheral blood mononuclear cells were examined to determine RSV-specific intracellular T helper- 1 (Th1) and T helper- 2 (Th2) cytokine expression, chemokine messenger RNA (mRNA) expression, and cell surface markers. Patients hospitalized because of RSV infection had increased numbers of CD16⁺ and$CD56^{bright}$cells and had RSV-specific increases in Th1 (interleukin [IL]-2 and interferon-γ) and Th2 (IL-4 and IL-6) cytokines and CC chemokines (macrophage inflammatory protein [MIP]-1α, MIP-1β, and RANTES [regulated on activation, normally T cell expressed and secreted]) mRNA expression. The results suggest that RSV infection induces both Th1 and Th2 cytokine expression and CC chemokine expression.