Journal of medicinal chemistry, 2002-05, Vol.45 (10), p.1959-1962
2002
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Details
- Autor(en) / Beteiligte
- Titel
- Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens
- Ist Teil von
- Journal of medicinal chemistry, 2002-05, Vol.45 (10), p.1959-1962
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 2002
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Potent nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase have been derived from a file compound high throughput screening hit. Optimized compounds show excellent antibacterial activity against staphylococcal and enterococcal pathogens, including strains resistant to clinical antibiotics. Compound 11 demonstrated in vivo efficacy in an S. aureus rat abscess infection model.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-2623eISSN: 1520-4804DOI: 10.1021/jm025502xTitel-ID: cdi_proquest_miscellaneous_71653625
- Format
- –
- Schlagworte
- Abscess - drug therapy, Abscess - microbiology, Animals, Anti-Bacterial Agents - chemical synthesis, Anti-Bacterial Agents - chemistry, Anti-Bacterial Agents - pharmacology, Antibacterial agents, Antibiotics. Antiinfectious agents. Antiparasitic agents, Biological and medical sciences, Drug Resistance, Bacterial, Enterococcus - drug effects, Enzyme Inhibitors - chemical synthesis, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, Medical sciences, Methionine-tRNA Ligase - antagonists & inhibitors, Pharmacology. Drug treatments, Quinolones - chemical synthesis, Quinolones - chemistry, Quinolones - pharmacology, Rats, Rats, Sprague-Dawley, Staphylococcus - drug effects, Staphylococcus aureus - drug effects, Staphylococcus aureus - enzymology, Structure-Activity Relationship