Amino acids, 2008-06, Vol.35 (1), p.247-249
2008
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Low dose domoic acid in neonatal rats abolishes nicotine induced conditioned place preference during late adolescence
- Ist Teil von
- Amino acids, 2008-06, Vol.35 (1), p.247-249
- Ort / Verlag
- Vienna: Vienna : Springer-Verlag
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In this study, neonatal rats were chronically exposed to low, non-convulsive doses of the kainate receptor agonist domoic acid (DOM), or saline. Later, as adolescents, all animals were tested in a nicotine-induced conditioned place preference (CPP) paradigm. As expected, a nicotine-induced CPP was evident in the adolescent control rats, but surprisingly, not in the DOM animals. This study demonstrates the importance of KA receptors in the development of normal adolescent behaviors manifested in response to the rewarding properties of nicotine.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0939-4451eISSN: 1438-2199DOI: 10.1007/s00726-007-0584-2Titel-ID: cdi_proquest_miscellaneous_71638029
- Format
- –
- Schlagworte
- Addiction, Analytical Chemistry, Animals, Animals, Newborn, Behavior, Animal - drug effects, Biochemical Engineering, Biochemistry, Biomedical and Life Sciences, Brain development, Kainate receptors, Kainic Acid - analogs & derivatives, Kainic Acid - pharmacology, Life Sciences, Mesocorticolimbic pathway, Neurobiology, Neuromuscular Depolarizing Agents - pharmacology, Nicotine, Nicotine - pharmacology, Nicotinic Agonists - pharmacology, Proteomics, Rats, Rats, Sprague-Dawley, Receptors, Kainic Acid - agonists, Receptors, Kainic Acid - metabolism, Reward behaviour, Rodents, Short Communication