Details

Autor(en) / Beteiligte

• Vásquez-Garibay, Edgar
• Campollo-Rivas, Octavio
• Romero-Velarde, Enrique
• Méndez-Estrada, Concepción
• García-Iglesias, Trinidad
• Alvizo-Mora, José Guadalupe
• Vizmanos-Lamotte, Barbara

Titel

Effect of Renutrition on Natural and Cell-Mediated Immune Response in Infants With Severe Malnutrition

Ist Teil von

• Journal of pediatric gastroenterology and nutrition, 2002-03, Vol.34 (3), p.296-301

Ort / Verlag

Hagerstown, MD: Lippincott Williams & Wilkins, Inc

Erscheinungsjahr

2002

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• BACKGROUNDThe purpose of this study was to evaluate whether a 4-week nutritional recovery period with a starting infant formula and 3.35 kJ/mL energy density would favorably affect the natural and cell-mediated immune response in infants with severe and primary protein-energy malnutrition. METHODOLOGYThe study included 12 severely malnourished infants, 3 to 18 months of age. For 2 weeks, infants were fed a starting infant formula, with energy density increased to 0.8 kcal/mL, through a nasogastric tube. Infants were fed “ad libitum” for 2 more weeks. On the fifth day, 837 kJ/kg and 4 g/kg protein were given daily. At the beginning and at the end of the 4-week period, weight, length, phagocytosis, microbicidal activity, chemotaxis, and cell proliferation indices were measured. Null hypothesis was rejected with a paired t test and a P value less than 0.05. RESULTSAfter the 4-week period of nutritional recovery, the weight and length indicators and the four immunologic assays showed significant increase (P < 0.005). CONCLUSIONThe study demonstrated that a 4-week nutritional recovery period with a starting infant formula and 0.8 kcal/mL energy density favorably affected the natural and cell-mediated immune response in infants with severe protein-energy malnutrition.