International journal of cancer, 2002-04, Vol.98 (6), p.883-888
2002
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- Autor(en) / Beteiligte
- Titel
- Prognostic significance of Ep‐CAM AND Her‐2/neu overexpression in invasive breast cancer
- Ist Teil von
- International journal of cancer, 2002-04, Vol.98 (6), p.883-888
- Ort / Verlag
- New York: Wiley Subscription Services, Inc., A Wiley Company
- Erscheinungsjahr
- 2002
- Quelle
- Wiley Online Library Journals Frontfile Complete
- Beschreibungen/Notizen
- To assess the frequency and prognostic impact of Ep‐CAM and Her‐2/neu overexpression in patients with breast cancer and to determine its relationship with other prognostic markers, 205 breast cancer patients with a median follow‐up of 10.8 years were enrolled in this retrospective study. Overexpression of Ep‐CAM and Her‐2/neu in tumor tissue samples was assessed by immunohistochemistry. Tumors presenting a Her‐2/neu 2+ staining were additionally analyzed by FISH to exclude false positive results. Ep‐CAM and Her‐2/neu overexpression was found in 35.6% and 19.5% of the tumor samples, respectively. Both Ep‐CAM and Her‐2/neu overexpression were predictive for poor disease‐free (DFS) and disease‐related overall survival (DROS). Concurrent Ep‐CAM and Her‐2/neu overexpression was present in 13.2% of tumor specimens and had an additive negative impact on DFS and DROS. This minority of patients had a median time to relapse of only 34 months, whereas the median time to relapse was not reached in the patient population without Her‐2/neu and Ep‐CAM overexpression. By multivariate analysis Ep‐CAM overexpression proved to be an indicator of poor prognosis, independent of tumor size, histologic grade, hormone receptor expression and Her‐2/neu overexpression. In conclusion, overexpression of Ep‐CAM and Her‐2/neu complement each other as predictors for poor prognosis in patients with invasive breast cancer. Determination of these tumor markers should help in assigning breast cancer patients to 1 of 3 distinct risk categories. © 2002 Wiley‐Liss, Inc.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0020-7136eISSN: 1097-0215DOI: 10.1002/ijc.10270Titel-ID: cdi_proquest_miscellaneous_71591515
- Format
- –
- Schlagworte
- Adult, Aged, Aged, 80 and over, Antigens, Neoplasm - genetics, Antigens, Neoplasm - metabolism, Biological and medical sciences, Biomarkers, Tumor - genetics, Biomarkers, Tumor - metabolism, breast, Breast Neoplasms - metabolism, Breast Neoplasms - pathology, cancer, Carcinoma, Ductal, Breast - metabolism, Carcinoma, Ductal, Breast - pathology, Carcinoma, Lobular - metabolism, Carcinoma, Lobular - pathology, CD3 Complex - genetics, CD3 Complex - metabolism, Cell Adhesion Molecules - genetics, Cell Adhesion Molecules - metabolism, Disease-Free Survival, Epithelial Cell Adhesion Molecule, Ep‐CAM, Female, Gynecology. Andrology. Obstetrics, Her‐2/neu, Humans, Immunoenzyme Techniques, In Situ Hybridization, Fluorescence, Mammary gland diseases, Medical sciences, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Prognosis, Receptor, ErbB-2 - genetics, Receptor, ErbB-2 - metabolism, Receptors, Estrogen - metabolism, Receptors, Progesterone - metabolism, Retrospective Studies, Tumors