Bioorganic & medicinal chemistry, 2002-06, Vol.10 (6), p.1711-1717
2002
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Details
- Autor(en) / Beteiligte
- Titel
- Metabolites of Orally Active NO-Independent Pyrazolopyridine Stimulators of Soluble Guanylate Cyclase
- Ist Teil von
- Bioorganic & medicinal chemistry, 2002-06, Vol.10 (6), p.1711-1717
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2002
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- The pyrazolopyridine stimulators of soluble guanylate cyclase BAY 41-2272 and 41-8543 were oxidised in rats and dogs at their 5-pyrimidinyl-cyclopropyl and -morpholino residue. These metabolites activate the soluble guanylate cyclase, induce vasoelaxation and thereby may contribute to the in vivo activity of BAY 41-2272 and BAY 41-8543. The stimulators of soluble guanylate cyclase BAY 41-2272 and BAY 41-8543 were oxidised in vivo in rats and dogs at their 5-pyrimidinyl-cyclopropyl and-morpholino residue, respectively, to yield metabolites with vasorelaxing activity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0968-0896eISSN: 1464-3391DOI: 10.1016/S0968-0896(02)00034-2Titel-ID: cdi_proquest_miscellaneous_71586524
- Format
- –
- Schlagworte
- Administration, Oral, Animals, Antianginal agents. Coronary vasodilator agents, Aorta - drug effects, Biological and medical sciences, Blood Pressure - drug effects, Cardiovascular system, Crystallography, X-Ray, Dogs, Enzyme Activation - drug effects, Guanylate Cyclase - chemistry, Guanylate Cyclase - metabolism, In Vitro Techniques, Injections, Intravenous, Lung - drug effects, Lung - enzymology, Medical sciences, Molecular Structure, Morpholines - administration & dosage, Morpholines - blood, Morpholines - metabolism, Morpholines - pharmacology, Nitric Oxide - metabolism, Pharmacology. Drug treatments, Pyrazoles - administration & dosage, Pyrazoles - blood, Pyrazoles - metabolism, Pyrazoles - pharmacology, Pyridines - administration & dosage, Pyridines - blood, Pyridines - metabolism, Pyridines - pharmacology, Pyrimidines - administration & dosage, Pyrimidines - blood, Pyrimidines - metabolism, Pyrimidines - pharmacology, Rats, Rats, Wistar, Solubility, Vasodilation - drug effects