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In the
Drosophila circadian clock, daily cycles in the RNA levels of
dclock (dClk) are antiphase to those of
period (
per). We altered the timing/levels of
dClk expression by generating transgenic flies whereby
per circadian regulatory sequences were used to drive rhythmic transcription of
dClk. The results indicate that posttranscriptional mechanisms make substantial contributions to the temporal changes in the abundance of the dCLK protein. Circadian regulation is largely unaffected in the transgenic
per-
dClk flies despite higher mean levels of dCLK. However, in
per-dClk flies the duration of morning activity is lengthened in light-dark cycles and light pulses evoke longer lasting bouts of activity. Our findings suggest that, in addition to a role in generating circadian rhythms, dCLK modulates the direct effects of light on locomotion.