Details

Autor(en) / Beteiligte

• Gu, Yu Gui
• Florjancic, Alan S.
• Clark, Richard F.
• Zhang, Tianyuan
• Cooper, Curt S.
• Anderson, David D.
• Lerner, Claude G.
• McCall, J.Owen
• Cai, Yingna
• Black-Schaefer, Candace L.
• Stamper, Geoffrey F.
• Hajduk, Philip J.
• Beutel, Bruce A.

Titel

Structure–activity relationships of novel potent MurF inhibitors

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.267-270

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• A novel class of MurF inhibitors was discovered and structure–activity relationship studies have led to several potent compounds with IC 50=22∼70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers. A novel class of MurF inhibitors was discovered and structure–activity relationship studies have led to several potent compounds with IC 50=22∼70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers.