Details

Autor(en) / Beteiligte

• Yamasaki, Kanji
• Noda, Shuji
• Imatanaka, Nobuya
• Yakabe, Yoshikuni

Titel

Comparative study of the uterotrophic potency of 14 chemicals in a uterotrophic assay and their receptor-binding affinity

Ist Teil von

• Toxicology letters, 2004-01, Vol.146 (2), p.111-120

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

2004

Quelle

ScienceDirect

Beschreibungen/Notizen

• We performed an immature rat uterotrophic assay of 14 chemicals having various receptor-binding affinities in order to assess the relationship between their uterotrophic potency and receptor-binding affinity. The chemicals tested were phthalic acid di- n-hexyl ester, phthalic acid di- n-amyl ester, phthalic acid di- n-propyl ester, 2-ethylhexyl- p-hydroxybenzoate, 4,4′-biphenol, 4,4′-sulfonyldiphenol, 4,4′-dihydroxydiphenylmethane, 2,4-dihydroxybenzophenone, 4,4′-cyclohexylidenebisphenol, 4- t-butylpyrocatechol, clomiphene citrate, 4,4′-(1,3-phenylenediisopropylidene)bisphenol, p- t-butylphenol, and diallylterephthlate. Two of the 14 chemicals, phthalic acid di- n-propyl ester and diallylterephthlate, exhibited no receptor-binding affinity, and the receptor-binding affinity of phthalic acid di- n-hexyl ester and phthalic acid di- n-amyl ester was lower than that of the other chemicals. Ten of the chemicals showed uterotrophic potency, the exceptions being phthalic acid di- n-propyl ester, diallylterephthlate, phthalic acid di- n-hexyl ester, and phthalic acid di- n-amyl ester. The results of the present study demonstrate that the affinity of the chemicals in the receptor-binding assay correlated well with their potency in the uterotrophic assay except for a few chemicals with very low receptor-binding affinity.