Details

Autor(en) / Beteiligte

• Ota, Martin O.C
• Vekemans, Johan
• Schlegel-Haueter, Susanna E
• Fielding, Katherine
• Whittle, Hilton
• Lambert, Paul-Henri
• McAdam, Keith P.W.J
• Siegrist, Claire-Anne
• Marchant, Arnaud

Titel

Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults

Ist Teil von

• Vaccine, 2004-01, Vol.22 (3), p.511-519

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2004

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• New-borns raise limited antibody responses to most T cell-dependent antigens but little is known about neonatal T lymphocyte responses to vaccines. In this study, we compared the immune response induced by the hepatitis B vaccine in new-borns and naı̈ve adults. Infants produced markedly higher serum anti-hepatitis B surface (HBs) antibody titres than adults. This was not associated with greater HBs Ag-specific Th2 cytokine responses but with lower primary IFN-γ responses. At 1 year, the infant memory response to HBs Ag was characterised by higher Th2 responses than those of adults. We conclude that neonatal antibody and T cell responses to hepatitis B vaccine differ from those induced in adults.