Details

Autor(en) / Beteiligte

• Migone, Thi-Sau
• Zhang, Jun
• Luo, Xia
• Zhuang, Li
• Chen, Cecil
• Hu, Bugen
• Hong, June S.
• Perry, James W.
• Chen, Su-Fang
• Zhou, Joe X.H.
• Cho, Yun Hee
• Ullrich, Stephen
• Kanakaraj, Palanisamy
• Carrell, Jeffrey
• Boyd, Ernest
• Olsen, Henrik S.
• Hu, Gang
• Pukac, Laurie
• Liu, Ding
• Ni, Jian
• Kim, Sunghee
• Gentz, Reiner
• Feng, Ping
• Moore, Paul A.
• Ruben, Steve M.
• Wei, Ping

Titel

TL1A Is a TNF-like Ligand for DR3 and TR6/DcR3 and Functions as a T Cell Costimulator

Ist Teil von

• Immunity (Cambridge, Mass.), 2002-03, Vol.16 (3), p.479-492

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2002

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• DR3 is a death domain-containing receptor that is upregulated during T cell activation and whose overexpression induces apoptosis and NF-κB activation in cell lines. Here we show that an endothelial cell-derived TNF-like factor, TL1A, is a ligand for DR3 and decoy receptor TR6/DcR3 and that its expression is inducible by TNF and IL-1α. TL1A induces NF-κB activation and apoptosis in DR3-expressing cell lines, while TR6-Fc protein antagonizes these signaling events. Interestingly, in T cells, TL1A acts as a costimulator that increases IL-2 responsiveness and secretion of proinflammatory cytokines both in vitro and in vivo. Our data suggest that interaction of TL1A with DR3 promotes T cell expansion during an immune response, whereas TR6 has an opposing effect.