Details

Autor(en) / Beteiligte

• Ruggeri, Loredana
• Capanni, Marusca
• Urbani, Elena
• Perruccio, Katia
• Shlomchik, Warren D.
• Tosti, Antonella
• Posati, Sabrina
• Rogaia, Daniela
• Frassoni, Francesco
• Aversa, Franco
• Martelli, Massimo F.
• Velardi, Andrea

Titel

Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants

Ist Teil von

• Science (American Association for the Advancement of Science), 2002-03, Vol.295 (5562), p.2097-2100

Ort / Verlag

Washington, DC: American Society for the Advancement of Science

Erscheinungsjahr

2002

Link zum Volltext

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• T cells that accompany allogeneic hematopoietic grafts for treating leukemia enhance engraftment and mediate the graft-versus-leukemia effect. Unfortunately, alloreactive T cells also cause graft-versus-host disease (GVHD). T cell depletion prevents GVHD but increases the risk of graft rejection and leukemic relapse. In human transplants, we show that donor-versus-recipient natural killer (NK)-cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against GVHD. In mice, the pretransplant infusion of alloreactive NK cells obviated the need for high-intensity conditioning and reduced GVHD. NK cell alloreactivity may thus provide a powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation.