Bioorganic & medicinal chemistry letters, 2002-04, Vol.12 (7), p.1063-1066
- FOLKES, Adrian
- BROWN, S. David
- LEAHY, James W
- MACH, Morrison
- MATTHEWS, David
- PRISBYLLA, Michael P
- SANDERSON, Jason
- SIMON, Reyna J
- TESFAI, Zerom
- VICKER, Nigel
- WANG, Shouming
- WEBB, Robert R
- CANNE, Lynne E
- CHARLTON, Peter
- CHAN, Jocelyn
- ENGELHARDT, Erin
- EPSHTEYN, Sergey
- FAINT, Richard
- GOLEC, Julian
- HANEL, Art
- KEARNEY, Patrick
2002
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- Autor(en) / Beteiligte
- FOLKES, Adrian
- BROWN, S. David
- LEAHY, James W
- MACH, Morrison
- MATTHEWS, David
- PRISBYLLA, Michael P
- SANDERSON, Jason
- SIMON, Reyna J
- TESFAI, Zerom
- VICKER, Nigel
- WANG, Shouming
- WEBB, Robert R
- CANNE, Lynne E
- CHARLTON, Peter
- CHAN, Jocelyn
- ENGELHARDT, Erin
- EPSHTEYN, Sergey
- FAINT, Richard
- GOLEC, Julian
- HANEL, Art
- KEARNEY, Patrick
- Titel
- Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2002-04, Vol.12 (7), p.1063-1066
- Ort / Verlag
- Oxford: Elsevier
- Erscheinungsjahr
- 2002
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These studies resulted in the identification of several compounds which showed excellent potency against PAI-1. The design, synthesis and SAR of these compounds are described.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/s0960-894x(02)00078-1Titel-ID: cdi_proquest_miscellaneous_71525879
- Format
- –
- Schlagworte
- Biological and medical sciences, Blood. Blood coagulation. Reticuloendothelial system, Chromogenic Compounds - chemistry, Drug Design, Drug Evaluation, Hydroxyquinolines - chemical synthesis, Hydroxyquinolines - chemistry, Hydroxyquinolines - pharmacology, In Vitro Techniques, Medical sciences, Molecular Structure, Pharmacology. Drug treatments, Plasminogen Activator Inhibitor 1 - chemical synthesis, Plasminogen Activator Inhibitor 1 - chemistry, Plasminogen Activator Inhibitor 1 - pharmacology, Pyrrolidinones - chemistry, Structure-Activity Relationship