Details

Autor(en) / Beteiligte

• WANG, Shao-Chun
• SHAO, Ruping
• PAO, Annie Y
• SU ZHANG
• HUNG, Mien-Chie
• SU, Li-Kuo

Titel

Inhibition of cancer cell growth by BRCA2

Ist Teil von

• Cancer research (Chicago, Ill.), 2002-03, Vol.62 (5), p.1311-1314

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

2002

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The breast cancer susceptibility gene BRCA2 has been suggested to function as a "caretaker" of the genome. Cells without wild-type BRCA2 are deficient in repairing DNA damage. However, whether BRCA2 can also suppress oncogenesis by regulating cell proliferation remains to be determined. To address this question, the expression of wild-type BRCA2 protein was reconstituted, in an either constitutive or regulated manner, in the pancreatic cancer cell line Capan-1, which expresses only a mutant BRCA2. Expression of wild-type BRCA2 inhibited cell proliferation in culture and suppressed tumor growth in animals. Our results showed that, in addition to the DNA repair function, BRCA2 also suppresses tumor development by inhibiting cancer cell growth.