Details

Autor(en) / Beteiligte

• Roman, Mary J
• Shanker, Beth-Ann
• Davis, Adrienne
• Lockshin, Michael D
• Sammaritano, Lisa
• Simantov, Ronit
• Crow, Mary K
• Schwartz, Joseph E
• Paget, Stephen A
• Devereux, Richard B
• Salmon, Jane E

Titel

Prevalence and Correlates of Accelerated Atherosclerosis in Systemic Lupus Erythematosus

Ist Teil von

• The New England journal of medicine, 2003-12, Vol.349 (25), p.2399-2406

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2003

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Patients with systemic lupus are at increased risk for myocardial infarction. In this study, the extent of carotid atherosclerosis was investigated by ultrasonography in patients with lupus and matched controls. Patients with lupus had premature atherosclerosis that was not related to traditional cardiovascular risk factors. Premature atherosclerosis not related to traditional risk factors. The diagnostic criteria for systemic lupus erythematosus, the prototypical autoimmune disease, focus on its major clinical manifestations, particularly renal, neurologic, and hematologic disease. In 1976, Urowitz et al. noted premature myocardial infarction among patients with lupus, 1 a finding confirmed by subsequent studies. 2 , 3 However, the reported cardiovascular outcomes are based on relatively few events, and the prevalence of atherosclerosis among patients with lupus and its relation to that in a control population are unknown. Furthermore, controversy remains regarding the mechanism of premature atherosclerosis. The prevailing hypothesis holds that premature atherosclerosis in lupus is attributable to an increased frequency of conventional . . .