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The Role of Retinoid X Receptor Messenger RNA Expression in Curatively Resected Non-Small Cell Lung Cancer
Ist Teil von
Clinical cancer research, 2002-02, Vol.8 (2), p.438-443
Ort / Verlag
Philadelphia, PA: American Association for Cancer Research
Erscheinungsjahr
2002
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Background: Retinoid X receptors (RXRs) have inhibitory effects on non-small cell lung cancer (NSCLC) cell growth, and RXRβ expression
is reduced in NSCLC specimens compared with normal lung tissue. We hypothesized that suppressed RXR expression might be a
prognostic factor of worse clinical outcome in patients with NSCLC.
Experimental Design: Using a quantitative real-time reverse transcription-PCR (TaqMan) method, we analyzed RXRα, RXRβ, and RXRγ mRNA expression
in normal lung tissue and matching tumor samples from 88 patients with NSCLC.
Results: The median mRNA expression levels of all three RXR subtypes were frequently decreased in tumor tissues compared with matching
normal lung tissue (RXRα, 67%; RXRβ, 55%; RXRγ, 89%). The RXRα ( P = 0.001) and RXRγ ( P < 0.001) median expression levels were significantly lower in the tumors. Patients whose tumors exhibited low RXRβ expression
levels had a statistically significant worse overall survival ( P = 0.0005), whereas a trend toward worse survival was observed for patients with low RXRα expression. Multivariate analysis
indicated that low RXRβ expression is an independent predictor of worse survival in patients with NSCLC ( P = 0.017).
Conclusion: Suppressed mRNA expression of all three RXR subtypes is a frequent event in NSCLC. Reduced RXRβ expression might be an important
biomarker for more aggressive disease in patients with NSCLC.