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Prognostic significance of Gleason pattern in patients with Gleason score 7 prostate carcinoma
Cancer, 2003-12, Vol.98 (12), p.2560-2565
Rasiah, Kris K.
Stricker, Phillip D.
Haynes, Anne‐Maree
Delprado, Warick
Turner, Jennifer J.
Golovsky, David
Brenner, Phillip C.
Kooner, Raji
O'Neill, Gordon F.
Grygiel, John J.
Sutherland, Robert L.
Henshall, Susan M.
2003
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Rasiah, Kris K.
Stricker, Phillip D.
Haynes, Anne‐Maree
Delprado, Warick
Turner, Jennifer J.
Golovsky, David
Brenner, Phillip C.
Kooner, Raji
O'Neill, Gordon F.
Grygiel, John J.
Sutherland, Robert L.
Henshall, Susan M.
Titel
Prognostic significance of Gleason pattern in patients with Gleason score 7 prostate carcinoma
Ist Teil von
Cancer, 2003-12, Vol.98 (12), p.2560-2565
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2003
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND In the current study, the authors sought to further stratify the prognosis of patients with Gleason score (GS) 7 prostate carcinoma. They assessed the influence on outcome of a predominant poorly differentiated Gleason pattern (primary Gleason pattern [GP] 4) and/or a coincident small focus of poorly differentiated tumor of higher grade (tertiary GP 5). METHODS The authors studied 412 patients (mean postoperative follow‐up, 33 months) with GS 7 tumors treated with radical prostatectomy at a single Australian campus between November 1989 and December 2002. The chi‐square test, Kaplan–Meier method, and Cox proportional hazards analyses were used to evaluate the correlation between primary GP 4 and tertiary GP 5 with the occurrence of adverse pathologic features and disease recurrence. RESULTS In this cohort, 307 patients (75%) had primary GP 3 tumors, 105 (25%) had primary GP 4 tumors, and 17 (2.3%) had a tertiary element of high‐grade tumor (GP 5). Patients with primary GP 4 tumors displayed higher rates of seminal vesicle involvement and extraprostatic extension and, along with patients with tertiary GP 5, had significantly shorter times to disease recurrence. Univariate analysis demonstrated that primary GP 4 (P = 0.0003) and tertiary GP 5 (P < 0.0001) were strong predictors of disease recurrence. Primary GP 4 (P = 0.0122) remained an independent predictor of disease recurrence on stepwise multivariate analysis. CONCLUSIONS Primary GP 4 tumors represented an aggressive subset of GS 7 prostate carcinomas. Primary GP was an easily accessible and clinically relevant predictor of disease recurrence in patients with GS 7 prostate carcinoma. Cancer 2003;98:2560–5. © 2003 American Cancer Society. Primary Gleason pattern was a clinically relevant predictor of outcome in patients with Gleason score 7 prostate carcinoma undergoing radical prostatectomy.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.11850
Titel-ID: cdi_proquest_miscellaneous_71452381
Format
–
Schlagworte
Biological and medical sciences
,
Disease Progression
,
Disease-Free Survival
,
Gleason pattern
,
Gleason score
,
Humans
,
Lymph Nodes - pathology
,
Lymphatic Metastasis
,
Male
,
Medical sciences
,
Neoplasm Invasiveness
,
Neoplasm Recurrence, Local - pathology
,
Neoplasm Staging
,
Nephrology. Urinary tract diseases
,
Prognosis
,
prostate carcinoma
,
Prostatic Neoplasms - pathology
,
Prostatic Neoplasms - surgery
,
Survival Rate
,
Tumors of the urinary system
,
Urinary tract. Prostate gland
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