Details

Autor(en) / Beteiligte

• MONTAVON, Celine
• VERGNE, Laurence
• BOURGEOIS, Anke
• MPOUDI-NGOLE, Eitel
• MALONGA-MOUELLET, Gabriel
• BUTEL, Christelle
• TOURE-KANE, Coumba
• DELAPORTE, Eric
• PEETERS, Martine

Titel

Identification of a new circulating recombinant form of HIV type 1, CRF11-cpx, involving subtypes A, G, J, and CRF01-AE, in Central Africa

Ist Teil von

• AIDS research and human retroviruses, 2002-02, Vol.18 (3), p.231-236

Ort / Verlag

Larchmont, NY: Liebert

Erscheinungsjahr

2002

Quelle

MEDLINE

Beschreibungen/Notizen

• In this study, we characterized three full-length genome sequences with a similar mosaic structure from epidemiologically unlinked individuals from Cameroon (97CM-MP818) and the Central African Republic (99CF-MP1298 and 99CF-MP1307). Phylogenetic and recombinant analysis confirmed that the three strains had a similar complex recombinant genome, which we can designate now as CRF11-cpx. This new CRF was composed of successive fragments of subtype A, G, J, and CRF01-AE. The previously reported GR17 virus from a Greek patient infected in the Democratic Republic of Congo (DRC) has a similar structure and should be considered as the prototype strain of CRF11-cpx. This new CRF circulates in Cameroon, Central African Republic, Gabon, and DRC, although the exact prevalences remain to be determined.