Details

Autor(en) / Beteiligte

• Zepik, Helmut
• Shavit, Edna
• Tang, Mao
• Jensen, Torben R.
• Kjaer, Kristian
• Bolbach, Gérard
• Leiserowitz, Leslie
• Weissbuch, Isabelle
• Lahav, Meir

Titel

Chiral Amplification of Oligopeptides in Two-Dimensional Crystalline Self-Assemblies on Water

Ist Teil von

• Science (American Association for the Advancement of Science), 2002-02, Vol.295 (5558), p.1266-1269

Ort / Verlag

Washington, DC: American Society for the Advancement of Science

Erscheinungsjahr

2002

Link zum Volltext

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Differences in the two-dimensional packing arrangements of racemic and enantiomeric crystalline self-assemblies on the water surface of amphiphilic activated analogs of lysine and glutamic acid have been used to prepare oligopeptides of homochiral sequence and oligopeptides of single handedness from chiral nonracemic mixtures. The crystalline structures on the water surface were determined by grazing incidence x-ray diffraction and the diastereomeric composition of the oligopeptides by matrix-assisted laser desorption time-of-flight mass spectrometry with enantio-labeling. These results suggest that reactivity of ordered clusters at interfaces might have played a role in the generation of early homochiral biopolymers.