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Ganciclovir therapy in cytomegalovirus (CMV) infection in immunocompetent pediatric patients
Ist Teil von
International journal of infectious diseases, 2003-12, Vol.7 (4), p.278-281
Ort / Verlag
Amsterdam: Elsevier Ltd
Erscheinungsjahr
2003
Quelle
MEDLINE
Beschreibungen/Notizen
Objectives: To evaluate the outcome of immunocompetent pediatric patients who had positive cytomegalovirus (CMV) antigenemia and received ganciclovir.
Methods: A retrospective review was done of patients who had a CMV infection based on positive antigenemia. Medical charts were reviewed for the following information: age, sex, underlying disease, symptoms and signs, laboratory results, complementary diagnostic procedures, duration and dose of ganciclovir therapy, concomitant medications, complications, and outcome.
Results: Sixty-four patients with positive CMV antigenemia were identified; 15 patients were excluded from the study because of their underlying diseases. Of the remaining 49 patients, 26 (53%) were female; the median age was 11.5 months (range 0.3–132 months). Sixty-one percent (30/49) of these patients received ganciclovir (5–10 mg/kg/day) for a median of 14 days (range 7–42 days). Clinical findings included: fever, anemia, hepatomegaly, failure to thrive, elevated liver enzymes, splenomegaly, seizures, and thrombocytopenia. Sixty-three percent (19/30) of the treated patients had negative antigenemia at the end of therapy. CMV antigenemia remained positive in six (20%) patients. Nine patients received a second course of ganciclovir.
Conclusions: Ganciclovir was effective in 80% of patients, as determined by negative antigenemia at the end of therapy.