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Corticostriatal Combinatorics: The Implications of Corticostriatal Axonal Arborizations
Ist Teil von
Journal of neurophysiology, 2002-02, Vol.87 (2), p.1007-1017
Ort / Verlag
United States: Am Phys Soc
Erscheinungsjahr
2002
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
1 Department of Neuroscience, The University
of Florida, Gainesville, Florida 32611; and
2 Cajal Neuroscience Research Center, University
of Texas at San Antonio, San Antonio, Texas 78249
Zheng, T. and
C. J. Wilson.
Corticostriatal Combinatorics: The Implications of
Corticostriatal Axonal Arborizations. J. Neurophysiol. 87: 1007-1017, 2002. The complete striatal axonal
arborizations of 16 juxtacellularly stained cortical pyramidal cells
were analyzed. Corticostriatal neurons were located in the medial
agranular or anterior cingulate cortex of rats. All axons were of the
extended type and formed synaptic contacts in both the striosomal and
matrix compartments as determined by counterstaining for the mu-opiate
receptor. Six axonal arborizations were from collaterals of brain
stem-projecting cells and the other 10 from bilaterally projecting
cells with no brain stem projections. The distribution of synaptic
boutons along the axons were convolved with the average dendritic tree volume of spiny projection neurons to obtain an axonal innervation volume and innervation density map for each axon. Innervation volumes
varied widely, with single axons occupying between 0.4 and 14.2% of
the striatum (average = 4%). The total number of boutons formed
by individual axons ranged from 25 to 2,900 (average = 879).
Within the innervation volume, the density of innervation was extremely
sparse but inhomogeneous. The pattern of innervation resembled
matrisomes, as defined by bulk labeling and functional mapping
experiments, superimposed on a low background innervation. Using this
sample as representative of all corticostriatal axons, the total number
of corticostriatal neurons was estimated to be 17 million, about 10 times the number of striatal projection neurons.