Details

Autor(en) / Beteiligte

• Nejentsev, Sergey
• Guja, Cristian
• McCormack, Rose
• Cooper, Jason
• Howson, Joanna MM
• Nutland, Sarah
• Rance, Helen
• Walker, Neil
• Undlien, Dag
• Ronningen, Kjersti S
• Tuomilehto-Wolf, Eva
• Tuomilehto, Jaakko
• Ionescu-Tirgoviste, Constantin
• Gale, Edwin AM
• Bingley, Polly J
• Gillespie, Kathleen M
• Savage, David A
• Carson, Dennis J
• Patterson, Chris C
• Maxwell, A Peter
• Todd, John A

Titel

Association of intercellular adhesion molecule-1 gene with type 1 diabetes

Ist Teil von

• The Lancet (British edition), 2003-11, Vol.362 (9397), p.1723-1724

Ort / Verlag

London: Elsevier Ltd

Erscheinungsjahr

2003

Quelle

Psychology & Behavioral Sciences Collection

Beschreibungen/Notizen

• Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the leucocyte integrins, in adhesion of immune cells to endothelial cells and in T cell activation. The third immuno-globulin-like extracellular domain binds integrin Mac-1 and contains a common non-conservative aminoacid polymorphism, G241R. Phenotypically, ICAM-1 has been associated with type 1 diabetes, a T-cell-mediated autoimmune disease. We assessed two independent datasets, and noted that R241 was associated with lower risk of type 1 diabetes than is G241 (3695 families, relative risk 0·91, p=0·03; 446 families, 0·60, p=0·006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments.