Details

Autor(en) / Beteiligte

• Schulze, Kerry J.
• O'Brien, Kimberly O.
• Germain-Lee, Emily L.
• Baer, David J.
• Leonard, Amanda L.R.
• Rosenstein, Beryl J.

Titel

Endogenous fecal losses of calcium compromise calcium balance in pancreatic-insufficient girls with cystic fibrosis

Ist Teil von

• The Journal of pediatrics, 2003-12, Vol.143 (6), p.765-771

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• Bone mineral density is compromised in individuals with cystic fibrosis (CF); calcium is the major bone mineral. This study examined the impact of endogenous fecal calcium (V endo) losses on calcium balance in girls with CF. V endo was measured in 12 girls with CF (aged 7-18 years): 7 younger, premenarcheal girls with compromised nutritional status; and 5 older, postmenarcheal girls with adequate nutritional status. V endo was measured as the amount of intravenously administered 42Ca, a calcium stable isotope, in stool relative to urine over 6 days. V endo was compared between pre- and postmenarcheal girls by Student's t test. Actual calcium balance [absorbed calcium−(urinary calcium (V u) + V endo)] was compared with estimated balance (assuming V endo = 1.6 mg/kg/day calcium) by paired t test. V endo was 99.3±42.3 mg/day. By body weight, V endo was highest among premenarcheal girls (3.37±1.09 mg/kg/day), resulting in excess losses (>1.6 mg/kg/day) of 55.0±45.7 mg/day. Over 1 year, this represents 20.1±16.7 g of unattained bone calcium or 6.7±4.2% of the bone calcium content of these girls. V endo is a significant source of calcium loss in individuals with CF and may limit calcium availability for bone mineral deposition.