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Productive infection of dendritic cells by simian immunodeficiency virus in macaque intestinal tissues
The Journal of pathology, 2003-12, Vol.201 (4), p.616-628
Choi, Yang Kyu
Whelton, Kelly M
Mlechick, Brandy
Murphey-Corb, Michael A
Reinhart, Todd A
2003
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Choi, Yang Kyu
Whelton, Kelly M
Mlechick, Brandy
Murphey-Corb, Michael A
Reinhart, Todd A
Titel
Productive infection of dendritic cells by simian immunodeficiency virus in macaque intestinal tissues
Ist Teil von
The Journal of pathology, 2003-12, Vol.201 (4), p.616-628
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2003
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Dendritic cells (DCs) are potent antigen‐presenting cells that likely play multiple roles in human immunodeficiency virus‐1 (HIV‐1) and simian immunodeficiency virus (SIV) pathogenesis. This paper describes the effects of pathogenic SIV infection on the networks of DCs in rhesus macaque (Macaca mulatta) intestinal tissues. Intestinal tissues were obtained from macaques at different stages of disease following infection with the pathogenic SIV/DeltaB670 isolate. The patterns and levels of expression of SIV and DC‐associated mRNAs were examined and quantitated directly in intestinal tissue sections. In situ hybridization was performed for SIV, DC‐specific ICAM3‐grabbing non‐integrin (DC‐SIGN), DC‐specific lysosome‐associated membrane glycoprotein (DC‐LAMP), DC‐specific C‐type lectin 1 (DECTIN‐1), CC chemokine receptor 6 (CCR6), CCR7, and macrophage inflammatory protein 3α (MIP‐3α/CCL20) mRNAs and quantitative image analysis was performed to measure mRNA expression levels. To identify the cell types productively infected by SIV, simultaneous in situ hybridization and immunohistochemical staining were performed. The DC networks in macaque intestinal tissues were found to be extensive and although they generally remained intact during the course of SIV infection, there were alterations in the expression of markers for immature DCs. One alteration was an increase in the expression in intestinal submucosa of DC‐SIGN, a molecule that binds to HIV‐1/SIV and increases its infectivity. Concomitant with this increase, it was found that during AIDS, the population of productively infected cells included DCs, based on co‐expression of DC‐SIGN and DECTIN‐1 mRNAs. These data indicate that SIV infection affects subpopulations of macaque intestinal DCs, including productive infection of DC‐SIGN+ DCs, the consequences of which are likely to be ongoing viral propagation and decreased immunostimulatory function. Copyright © 2003 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/path.1482
Titel-ID: cdi_proquest_miscellaneous_71426622
Format
–
Schlagworte
Acquired Immunodeficiency Syndrome - pathology
,
Animals
,
Antigens, CD - analysis
,
Antigens, Differentiation, Myelomonocytic - analysis
,
Biological and medical sciences
,
Biomarkers - analysis
,
chemokine
,
Chemokines - analysis
,
Colon - pathology
,
Colon - virology
,
dendritic cell
,
Dendritic Cells - virology
,
Epithelium - pathology
,
Epithelium - virology
,
HIV-1
,
HLA-DR Antigens - analysis
,
Human viral diseases
,
Immunohistochemistry - methods
,
in situ hybridisation
,
In Situ Hybridization - methods
,
Infectious diseases
,
Intestinal Diseases - pathology
,
Intestinal Mucosa - pathology
,
Intestinal Mucosa - virology
,
intestine
,
Jejunum - pathology
,
Jejunum - virology
,
Macaca mulatta
,
Medical sciences
,
Muscle, Smooth - pathology
,
Muscle, Smooth - virology
,
pathogenesis
,
Peyer's Patches - pathology
,
Peyer's Patches - virology
,
Receptors, Chemokine - analysis
,
RNA, Messenger - analysis
,
RNA, Viral - analysis
,
Simian Acquired Immunodeficiency Syndrome - pathology
,
Simian Immunodeficiency Virus - pathogenicity
,
SIV
,
tropism
,
Viral diseases
,
Viral diseases of the lymphoid tissue and the blood. Aids
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