Details

Autor(en) / Beteiligte

• Aoki, Kumiko
• Sun, Ying-Jie
• Aoki, Shunsuke
• Wada, Keiji
• Wada, Etsuko

Titel

Cloning, Expression, and Mapping of a Gene That Is Upregulated in Adipose Tissue of Mice Deficient in Bombesin Receptor Subtype-3

Ist Teil von

• Biochemical and biophysical research communications, 2002-02, Vol.290 (4), p.1282-1288

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2002

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• To identify novel obesity-related genes in adipose tissue, differential display was performed using bombesin receptor subtype-3 (BRS-3)-deficient mice. These mice exhibit mild late-onset obesity. We report that a gene, Urb, is upregulated in these mice. Full-length Urb cDNA is approximately 3 kb long and comprises an open reading frame of 949 amino acid residues. Interestingly, Urb mRNA expression in brown adipose tissue of BRS-3-deficient mice is fourfold higher than that in wild-type controls. Enhanced Urb mRNA expression was also observed in brain, digestive tissues, kidney, and lung. Within the brain, Urb mRNA is detected in the dorsal endopiriform nucleus and choroid plexus. A T31 radiation hybrid mapping panel revealed that the Urb gene maps to mouse chromosome 16. Collectively, these findings suggest that Urb may have a unique function in the regulation of body weight and energy metabolism.