Details

Autor(en) / Beteiligte

• Nakae, Susumu
• Nambu, Aya
• Sudo, Katsuko
• Iwakura, Yoichiro

Titel

Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

Ist Teil von

• The Journal of immunology (1950), 2003-12, Vol.171 (11), p.6173-6177

Ort / Verlag

United States: Am Assoc Immnol

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• Interleukin-17 is a T cell-derived proinflammatory cytokine. This cytokine is suspected to be involved in the development of rheumatoid arthritis (RA) because this cytokine expression is augmented in synovial tissues of RA patients. The pathogenic roles of IL-17 in the development of RA, however, still remain to be elucidated. In this study, effects of IL-17 deficiency on collagen-induced arthritis (CIA) model were examined using IL-17-deficient mice (IL-17(-/-) mice). We found that CIA was markedly suppressed in IL-17(-/-) mice. IL-17 was responsible for the priming of collagen-specific T cells and collagen-specific IgG2a production. Thus, these observations suggest that IL-17 plays a crucial role in the development of CIA by activating autoantigen-specific cellular and humoral immune responses.