Details

Autor(en) / Beteiligte

• Swalwell, Jennifer I.
• Vocke, Cathy D.
• Yang, Youfeng
• Walker, Jonathan R.
• Grouse, Lynette
• Myers, Stuart H.
• Gillespie, John W.
• Bostwick, David G.
• Duray, Paul H.
• Linehan, W. Marston
• Emmert-Buck, Michael R.

Titel

Determination of a minimal deletion interval on chromosome band 8p21 in sporadic prostate cancer

Ist Teil von

• Genes chromosomes & cancer, 2002-02, Vol.33 (2), p.201-205

Ort / Verlag

New York: John Wiley & Sons, Inc

Erscheinungsjahr

2002

Quelle

MEDLINE

Beschreibungen/Notizen

• Loss of the short arm of chromosome 8 is a common event in prostatic neoplasms. Previous studies indicate that there may be up to three separate tumor suppressor genes on chromosome arm 8p, based on patterns of allelic loss. The responsible gene or genes have yet to be identified. In the present study, we used laser‐capture microdissection of primary human prostate tumors and 17 microsatellite markers across chromosome band 8p21 to determine a minimal deletion interval. From an initial set of 120 cases, three tumors contained overlapping interstitial deletions on chromosome band 8p21. The three cases define an internally consistent minimal candidate tumor suppressor gene interval of approximately two megabases. Published 2002 Wiley‐Liss, Inc.