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Results of a genome-wide linkage analysis in prostate cancer families ascertained through the ACTANE consortium
The Prostate, 2003-12, Vol.57 (4), p.270-279
Edwards, Steve
Meitz, Julia
Eles, Ros
Evans, Chris
Easton, Doug
Hopper, John
Giles, Graham
Foulkes, William D
Narod, Steven
Simard, Jacques
Badzioch, Mike
Mahle, Lovise
2003
Details
Autor(en) / Beteiligte
Edwards, Steve
Meitz, Julia
Eles, Ros
Evans, Chris
Easton, Doug
Hopper, John
Giles, Graham
Foulkes, William D
Narod, Steven
Simard, Jacques
Badzioch, Mike
Mahle, Lovise
Titel
Results of a genome-wide linkage analysis in prostate cancer families ascertained through the ACTANE consortium
Ist Teil von
The Prostate, 2003-12, Vol.57 (4), p.270-279
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2003
Link zum Volltext
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
BACKGROUND The aggregation of prostate cancer within families suggests a major inherited component to the disease. Genetic linkage studies have identified several chromosomal regions that may contain prostate cancer susceptibility loci, but none has been definitively implicated. METHODS We performed a genome‐wide linkage search based on 64 families, 63 with at least 3 cases of prostate cancer, ascertained in five countries. The majority of cases from these centers presented with clinically detected disease. Four hundred and one polymorphic markers were typed in 268 individuals. Multipoint heterogeneity analysis was conducted under three models of susceptibility; non‐parametric analyses were also performed. RESULTS Some weak evidence of linkage, under at least one of the genetic models, was observed to markers on chromosomes 2 (heterogeneity LOD (HLOD) = 1.15, P = 0.021), 3 (HLOD = 1.25, P = 0.016), 4 (HLOD = 1.28, P = 0.015), 5 (HLOD = 1.20, P = 0.019), 6 (HLOD = 1.41, P = 0.011), and 11 (HLOD = 1.24, P = 0.018), and in two regions on chromosome 18 (HLOD = 1.40, P = 0.011 and HLOD = 1.34, P = 0.013). There were no HLOD scores greater than 1.5 under any model, and no locus would be predicted to explain more than half of the genetic effect. No evidence in favor of linkage to previously suggested regions on chromosomes 1, 8, 17, 20, or X was found. CONCLUSIONS Genetic susceptibility to prostate cancer is likely to be controlled by many loci, with no single gene explaining a large fraction of the familial risk. Pooling of results from all available genome scans is likely to be required to obtain definitive linkage results. Prostate 57: 270–279, 2003. © 2003 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0270-4137
eISSN: 1097-0045
DOI: 10.1002/pros.10301
Titel-ID: cdi_proquest_miscellaneous_71348590
Format
–
Schlagworte
ACTANE
,
Adult
,
Age of Onset
,
Aged
,
Aged, 80 and over
,
Biological and medical sciences
,
DNA, Neoplasm - chemistry
,
DNA, Neoplasm - genetics
,
Family
,
Female
,
Genetic Linkage - genetics
,
Genetic Predisposition to Disease
,
genome search
,
Genome, Human
,
Humans
,
linkage
,
Male
,
Medical sciences
,
Microsatellite Repeats - genetics
,
Middle Aged
,
Nephrology. Urinary tract diseases
,
Polymerase Chain Reaction
,
prostate cancer
,
Prostatic Neoplasms - genetics
,
Sequence Analysis, DNA
,
Tumors of the urinary system
,
Urinary tract. Prostate gland
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